Structure of PDB 4nra Chain A

Receptor sequence
>4nraA (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
SMSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVI
KKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGH
NMRKYFEKKWTDTFKV
3D structure
PDB4nra Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2LW A P1888 N1944 I1950 P33 N89 I95 MOAD: Kd=65uM
PDBbind-CN: -logKd/Ki=4.19,Kd=65uM
BindingDB: IC50=37000nM,Kd=65000nM
External links
PDB RCSB:4nra, PDBe:4nra, PDBj:4nra
PDBsum4nra
PubMed24304323
UniProtQ9UIF8|BAZ2B_HUMAN Bromodomain adjacent to zinc finger domain protein 2B (Gene Name=BAZ2B)

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