Structure of PDB 4nr7 Chain A

Receptor sequence
>4nr7A (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKN
PMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKL
AEVFEQEIDPVMQSLG
3D structure
PDB4nr7 Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand
ChainA
Resolution1.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2LO A P1110 V1115 L1120 N1168 R1173 V1174 F1177 P29 V34 L39 N87 R92 V93 F96 BindingDB: Kd=21nM,IC50=2800nM,EC50=6900nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4nr7, PDBe:4nr7, PDBj:4nr7
PDBsum4nr7
PubMed
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

[Back to BioLiP]