Structure of PDB 4nqa Chain A

Receptor sequence
>4nqaA (length=317) Species: 9606 (Homo sapiens) [Search protein sequence]
ASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDC
LIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGSSANEDMPVERILEA
ELAVEPKTETYEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHF
SELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHS
AGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEV
EALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFF
KLIGDTPIDTFLMEMLE
3D structure
PDB4nqa Structure of the retinoid X receptor alpha-liver X receptor beta (RXR alpha-LXR beta ) heterodimer on DNA.
ChainA
Resolution3.102 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F277 K284 L294 V298 E453 F138 K145 L155 V159 E314
BS02 dna A K145 H146 K160 R164 Q206 E207 K18 H19 K33 R37 Q79 E80
BS03 dna A E153 G154 F158 R161 R184 N185 Q188 R191 E26 G27 F31 R34 R57 N58 Q61 R64
BS04 9CR A I268 Q275 F313 A327 C432 I129 Q136 F174 A188 C293 BindingDB: EC50=100nM,Ki=583nM,IC50=32nM,Kd=240nM
BS05 ZN A C135 C155 C8 C28
BS06 ZN A C171 C177 C190 C44 C50 C63
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4nqa, PDBe:4nqa, PDBj:4nqa
PDBsum4nqa
PubMed24561505
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

[Back to BioLiP]