Structure of PDB 4nmm Chain A

Receptor sequence
>4nmmA (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKEK
3D structure
PDB4nmm In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
ChainA
Resolution1.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y9Z A C12 G13 V14 G15 K16 S17 A18 F28 D30 P34 A59 N116 K117 D119 L120 S145 A146 C13 G14 V15 G16 K17 S18 A19 F29 D31 P35 A60 N117 K118 D120 L121 S146 A147
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4nmm, PDBe:4nmm, PDBj:4nmm
PDBsum4nmm
PubMed24889603
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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