Structure of PDB 4nme Chain A

Receptor sequence
>4nmeA (length=972) Species: 243231 (Geobacter sulfurreducens PCA) [Search protein sequence]
SMLNSELNTKIVNRGKEFFGSIPSLFNKGAWMGKAMDWSMQNEQFKIQMF
RFVDVFPSLTTSKLLTEHIREYFGNEQDMPAFVLNKVLTSNIEEMARQFI
VGETTKEAVKNLEKLRKDGFAAVVDVLGEATLSEEEAEVYTNTYLELLEA
LKKEQGSWKGLPGKGGDPGLDWGHAPKVNIAVKPTALFCLANPQDFEGSV
VAILDRMRRIFKKVMELNGFLCIDMESYRHKEIILEVFRRLKLEYRDYPH
LGIVLQAYLKDNDKDLDDLLAWAKEHKVQISVRLVKGAYWDYETVKAKQN
DWEVPVWTIKAESDAAYERQARKILENHQICHFACASHNIRTISAVMEMA
RELNVPEDRYEFQVLYGMVRKGILKVAGRIRLYAPYGNMVPGMGYLVRRL
LENTANESFLRQSFAEDAQIERLLEDPAVTVERERAARKGLGGLPPFNNE
AMVDFTRADHRAAFPKHIAQVRTQLGKTYPLFINGKEVRTNDLIPTVNPN
KPSEVLGQICQAGTTEVGDAIAAAKAAFPAWRDTDPRTRAEYLLKAAQAA
RKRLFELSAWQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGQPQRVG
HAPGELNHYFYEPKGVAAVIAPWNFPLAISMGMASAAIVTGNCVVFKPSG
ITSIIGWHLVELFREAGLPEGVFNFTPGRGSVMGDYLVDHPDISLIAFTG
SMETGLRIIERAAKVHPGQANVKKIISEMGGKNAIIIDDDADLDEAVPHV
LYSAFGFQGQKCSACSRVIVLDAVYDKFIERLVSMAKATKVGPSEDPANY
MGAVADDKAMKSIKEYAEIGKREGHVLYESPVPAGEGYFVPMTIIGGIKP
EHRIAQEEIFGPVLAVMRAKDFDQAIEWANSTQFALTGGIFSRSPEHLAK
ARREFRVGNLYINRNNTGALVERQPFGGARMSGVGTKAGGPDYLLHFMDP
RVVTENTMRRGFAPIEEDDDWV
3D structure
PDB4nme Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site.
ChainA
Resolution2.088 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N655 K678 E759 C793 E889 A969
Catalytic site (residue number reindexed from 1) N624 K647 E728 C762 E858 A938
Enzyme Commision number 1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P5F A K203 D244 M245 V274 Q276 R303 V305 K306 G307 A308 W310 W327 T328 I329 K330 S333 A356 S357 H358 N359 Q383 L385 Y406 E425 F432 K183 D224 M225 V254 Q256 R283 V285 K286 G287 A288 W290 W307 T308 I309 K310 S313 A336 S337 H338 N339 Q363 L365 Y383 E402 F409
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003700 DNA-binding transcription factor activity
GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
GO:0004657 proline dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006562 proline catabolic process
GO:0010133 proline catabolic process to glutamate
Cellular Component
GO:0005737 cytoplasm
GO:0009898 cytoplasmic side of plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4nme, PDBe:4nme, PDBj:4nme
PDBsum4nme
PubMed24550478
UniProtQ746X3

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