Structure of PDB 4nmd Chain A

Receptor sequence
>4nmdA (length=979) Species: 243231 (Geobacter sulfurreducens PCA) [Search protein sequence]
SMLNSELNTKIVNRGKEFFGSIPSLFNKGAWMGKAMDWSMQNEQFKIQMF
RFVDVFPSLTTSKLLTEHIREYFGNEQDMPAFMAVLNKVLTSNIEEMARQ
FIVGETTKEAVKNLEKLRKDGFAAVVDVLGEATLSEEEAEVYTNTYLELL
EALKKEQGSWKGLPGKGGDPGLDWGHAPKVNIAVKPTALFCLANPQDFEG
SVVAILDRMRRIFKKVMELNGFLCIDMESYRHKEIILEVFRRLKLEYRDY
PHLGIVLQAYLKDNDKDLDDLLAWAKEHKVQISVRLVKGAYWDYETVKAK
QNDWEVPVWTIKAESDAAYERQARKILENHQICHFACASHNIRTISAVME
MARELNVPEDRYEFQVLYGMAEPVRKGILKVAGRIRLYAPYGNMVPGMGY
LVRRLLENTANESFLRQSFAEDAQIERLLEDPAVTVERERAARAAKGLGG
LPPFNNEAMVDFTRADHRAAFPKHIAQVRTQLGKTYPLFINGKEVRTNDL
IPTVNPNKPSEVLGQICQAGTTEVGDAIAAAKAAFPAWRDTDPRTRAEYL
LKAAQAARKRLFELSAWQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRL
GQPQRVGHAPGELNHYFYEPKGVAAVIAPWNFPLAISMGMASAAIVTGNC
VVFKPSGITSIIGWHLVELFREAGLPEGVFNFTPGRGSVMGDYLVDHPDI
SLIAFTGSMETGLRIIERAAKVHPGQANVKKIISEMGGKNAIIIDDDADL
DEAVPHVLYSAFGFQGQKCSACSRVIVLDAVYDKFIERLVSMAKATKVGP
SEDPANYMGAVADDKAMKSIKEYAEIGKREGHVLYESPVPAGEGYFVPMT
IIGGIKPEHRIAQEEIFGPVLAVMRAKDFDQAIEWANSTQFALTGGIFSR
SPEHLAKARREFRVGNLYINRNNTGALVERQPFGGARMSGVGTKAGGPDY
LLHFMDPRVVTENTMRRGFAPIEEDDDWV
3D structure
PDB4nmd Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site.
ChainA
Resolution1.979 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N655 K678 E759 C793 E889 A969
Catalytic site (residue number reindexed from 1) N631 K654 E735 C769 E865 A945
Enzyme Commision number 1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FDA A D244 M245 V274 Q276 R303 V305 K306 G307 A308 W310 W327 T328 I329 K330 S333 A356 S357 H358 N359 Q383 V384 L385 Y406 F432 D226 M227 V256 Q258 R285 V287 K288 G289 A290 W292 W309 T310 I311 K312 S315 A338 S339 H340 N341 Q365 V366 L367 Y388 F414
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003700 DNA-binding transcription factor activity
GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
GO:0004657 proline dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006562 proline catabolic process
GO:0010133 proline catabolic process to glutamate
Cellular Component
GO:0005737 cytoplasm
GO:0009898 cytoplasmic side of plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4nmd, PDBe:4nmd, PDBj:4nmd
PDBsum4nmd
PubMed24550478
UniProtQ746X3

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