Structure of PDB 4nmb Chain A

Receptor sequence
>4nmbA (length=976) Species: 243231 (Geobacter sulfurreducens PCA) [Search protein sequence]
NSELNTKIVNRGKEFFGSISGEKPSLFNKGAWMGKAMDWSMQNEQFKIQM
FRFVDVFPSLTTSKLLTEHIREYFGNEQDMPAFMAVLNKVLTSNIEEMAR
QFIVGETTKEAVKNLEKLRKDGFAAVVDVLGEATLSEEEAEVYTNTYLEL
LEALKKEQGSWKGLPGKGGDPGLDWGHAPKVNIAVKPTALFCLANPQDFE
GSVVAILDRMRRIFKKVMELNGFLCIDMESYRHKEIILEVFRRLKLEYRD
YPHLGIVLQAYLKDNDKDLDDLLAWAKEHKVQISVRLVKGAYWDYETVKA
KQNDWEVPVWTIKAESDAAYERQARKILENHQICHFACASHNIRTISAVM
EMARELNVPEDRYEFQVLYGMAEPVRKGILKVAGRIRLYAPYGNMVPGMG
YLVRRLLENTANESFLRQSFAEDAQIERLLEDPAVTVERERAARLGGLPP
FNNEAMVDFTRADHRAAFPKHIAQVRTQLGKTYPLFINGKEVRTNDLIPT
VNPNKPSEVLGQICQAGTTEVGDAIAAAKAAFPAWRDTDPRTRAEYLLKA
AQAARKRLFELSAWQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGQP
QRVGHAPGELNHYFYEPKGVAAVIAPWNFPLAISMGMASAAIVTGNCVVF
KPSGITSIIGWHLVELFREAGLPEGVFNFTPGRGSVMGDYLVDHPDISLI
AFTGSMETGLRIIERAAKVHPGQANVKKIISEMGGKNAIIIDDDADLDEA
VPHVLYSAFGFQGQKCSACSRVIVLDAVYDKFIERLVSMAKATKVGPSED
PANYMGAVADDKAMKSIKEYAEIGKREGHVLYESPVPAGEGYFVPMTIIG
GIKPEHRIAQEEIFGPVLAVMRAKDFDQAIEWANSTQFALTGGIFSRSPE
HLAKARREFRVGNLYINRNNTGALVERQPFGGARMSGVGTKAGGPDYLLH
FMDPRVVTENTMRRGFAPIEEDDDWV
3D structure
PDB4nmb Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site.
ChainA
Resolution2.198 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N655 K678 E759 C793 E889 A969
Catalytic site (residue number reindexed from 1) N628 K651 E732 C766 E862 A942
Enzyme Commision number 1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A D244 M245 V274 Q276 R303 V305 K306 G307 A308 Y309 W310 W327 T328 I329 K330 S333 A356 S357 H358 N359 L385 E425 S431 F432 D227 M228 V257 Q259 R286 V288 K289 G290 A291 Y292 W293 W310 T311 I312 K313 S316 A339 S340 H341 N342 L368 E408 S414 F415
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003700 DNA-binding transcription factor activity
GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
GO:0004657 proline dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006562 proline catabolic process
GO:0010133 proline catabolic process to glutamate
Cellular Component
GO:0005737 cytoplasm
GO:0009898 cytoplasmic side of plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4nmb, PDBe:4nmb, PDBj:4nmb
PDBsum4nmb
PubMed24550478
UniProtQ746X3

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