Structure of PDB 4nl8 Chain A

Receptor sequence
>4nl8A (length=549) Species: 272620 (Klebsiella pneumoniae subsp. pneumoniae MGH 78578) [Search protein sequence]
MSVAHVALPVPLPRTFDYLLPEKAGCRVRVPFGKQERIGIVAAVLKPVLD
DEPVFSTTVWRLLMWAAEYYHHPIGDVLFHALPVMLRQGKPASATRLNTE
QATAVGAIHSAADRFSAWLLAGITGSGKTEVYLSVLENVLAQGRQALVMV
PEIGLTPQTIARFRQRFNAPVEVLHSGLNDSERLSAWLKAKNGEAAIVIG
TRSSLFTPFKDLGVIVIDEEHDSSYKQQEGWRYHARDLAVWRAHSEQIPI
ILGSATPALETLHNVRQGKYRQLTLSQQHVLDLKGQPLQAGLSPALISRM
RQHLQADNQVILFLNRRGFAPALLCHDCGWIAECPRCDSYYTLHQAQHHL
RCHHCDSQRPIPRQCPSCGSTHLVPVGIGTEQLEQALAPLLDVDGALFSA
DFRSAERFAQLYTQVSGRKQGEVILQTHHPEHPLLQTLLYKGYDAFAEQA
LAERQTMQLPPWTSHVLIRAEDHNNQQAPLFLQQLRNLLQASPLADEKLW
VLGPVPALARWQILLQHPSRVRLQHIVSGTLALINTLVKWVLDVDPIEG
3D structure
PDB4nl8 Structural mechanisms of PriA-mediated DNA replication restart.
ChainA
Resolution4.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C435 C438 C475 C478 C325 C328 C365 C368
BS02 ZN A C444 C447 C462 C465 C334 C337 C352 C355
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0043138 3'-5' DNA helicase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0032508 DNA duplex unwinding
Cellular Component
GO:1990077 primosome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4nl8, PDBe:4nl8, PDBj:4nl8
PDBsum4nl8
PubMed24379377
UniProtA6TGC5

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