Structure of PDB 4nks Chain A

Receptor sequence
>4nksA (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
LPEDPRWELPRDRLVLGKPLGQVVLAEAINRVTKVAVKMLKDATEKDLSD
LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR
PPQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD
FGLIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLG
GSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF
KQLVEDLDRIVALTS
3D structure
PDB4nks FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D623 A625 R627 N628 D641
Catalytic site (residue number reindexed from 1) D132 A134 R136 N137 D150
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2M2 A A512 K514 E531 V561 A564 L630 A36 K38 E54 V84 A87 L139 MOAD: Kd=69.1nM
PDBbind-CN: -logKd/Ki=7.17,Kd=67.9nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005007 fibroblast growth factor receptor activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4nks, PDBe:4nks, PDBj:4nks
PDBsum4nks
PubMed24900792
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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