Structure of PDB 4nj4 Chain A

Receptor sequence
>4nj4A (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
DYEEQQLQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLY
NEHTVDRAPLRNKYFFGEGYTYGAQPGQERLYPPGDVDEIPEWVHQLVIQ
KLVEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDS
ALCFGCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIK
ERRAVIILRKTRLDAPRL
3D structure
PDB4nj4 Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.
ChainA
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.53: mRNA N(6)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H204 D206 H266 H130 D132 H192
BS02 UN9 A R130 C200 I201 V202 Q233 R61 C126 I127 V128 Q159
Gene Ontology
Molecular Function
GO:0035515 oxidative RNA demethylase activity
Biological Process
GO:0006397 mRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:4nj4, PDBe:4nj4, PDBj:4nj4
PDBsum4nj4
PubMed24489119
UniProtQ6P6C2|ALKB5_HUMAN RNA demethylase ALKBH5 (Gene Name=ALKBH5)

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