Structure of PDB 4niv Chain A

Receptor sequence
>4nivA (length=193) Species: 9913 (Bos taurus) [Search protein sequence]
YTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYESGIQVRLGEDN
INVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASIS
LPTSCASAGTQCLISGWPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAG
YDSGGPVVCSGKLQGIVSWGSKPGVYTKVCNYVSWIKQTIASN
3D structure
PDB4niv N-terminal protein modification by substrate-activated reverse proteolysis.
ChainA
Resolution1.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 D194 S195 G196
Catalytic site (residue number reindexed from 1) H36 D80 D152 S153 G154
Enzyme Commision number 3.4.21.4: trypsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E70 N72 V75 E80 E48 N50 V53 E58
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
GO:0097655 serpin family protein binding
Biological Process
GO:0006508 proteolysis
GO:0007586 digestion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0097180 serine protease inhibitor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4niv, PDBe:4niv, PDBj:4niv
PDBsum4niv
PubMed24520050
UniProtP00760|TRY1_BOVIN Serine protease 1 (Gene Name=PRSS1)

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