Structure of PDB 4nie Chain A

Receptor sequence
>4nieA (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSM
WEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLV
RMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFS
EDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSIL
AKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFST
3D structure
PDB4nie Discovery of Tertiary Amine and Indole Derivatives as Potent ROR gamma t Inverse Agonists.
ChainA
Resolution2.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I492 Q495 A496 I229 Q232 A233
BS02 peptide A K336 I350 K354 P500 L501 E504 K73 I87 K91 P237 L238 E241
BS03 NBH A Q286 L287 W317 C320 R364 M365 R367 A368 F377 F378 F388 Q23 L24 W54 C57 R101 M102 R104 A105 F114 F115 F125 PDBbind-CN: -logKd/Ki=7.70,IC50=20nM
BindingDB: EC50=20nM,IC50=>25000nM
BS04 DMX A W314 H490 I492 V493 W51 H227 I229 V230
BS05 DMX A Y330 E333 Y67 E70
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4nie, PDBe:4nie, PDBj:4nie
PDBsum4nie
PubMed24900774
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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