Structure of PDB 4ni7 Chain A

Receptor sequence
>4ni7A (length=151) Species: 9606 (Homo sapiens) [Search protein sequence]
RQPLTSSERIDKQIRYILDGISALRKETCNKSNLNLPKMAEKDGCFQSGF
NEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQK
KAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQ
M
3D structure
PDB4ni7 Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R16 R24 K27 Q28 R30 Y31 L33 M117 S118 V121 F125 K171 Q175 L178 R1 R9 K12 Q13 R15 Y16 L18 M89 S90 V93 F97 K138 Q142 L145 PDBbind-CN: Kd=0.2nM
Gene Ontology
Molecular Function
GO:0005125 cytokine activity
GO:0005138 interleukin-6 receptor binding
Biological Process
GO:0006955 immune response
GO:0030154 cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ni7, PDBe:4ni7, PDBj:4ni7
PDBsum4ni7
PubMed24415767
UniProtP05231|IL6_HUMAN Interleukin-6 (Gene Name=IL6)

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