Structure of PDB 4nha Chain A

Receptor sequence
>4nhaA (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
LYVIGMVLTTPLPDELRKLYPPEDTTRCFGILTAKPIPQIPVYTRSGEVT
ISIELKKSGFMLSLQMLELITRLHQYIFSHILRLSAYCVLPLNVTLDIDF
KFMEDIEKSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYT
DLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTP
KQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
3D structure
PDB4nha A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
ChainA
Resolution3.401 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A Y926 R927 F950 F958 Y961 Y962 Y966 I1022 Y134 R135 F158 F166 Y169 Y170 Y174 I203
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4nha, PDBe:4nha, PDBj:4nha
PDBsum4nha
PubMed24486018
UniProtQ9UPY3|DICER_HUMAN Endoribonuclease Dicer (Gene Name=DICER1)

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