Structure of PDB 4nh5 Chain A

Receptor sequence
>4nh5A (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPH
FPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEKYCV
LPLNVVNSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDA
VIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDL
TNLNQPLLDVDHTSSRLNLLTPRHAEKRKAKWESLQNKQILVPELCAIHP
IPASLWRKAVCLPSILYRLHC
3D structure
PDB4nh5 A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A Y926 R927 F950 Y961 Y962 K965 Y966 W1014 L1017 Q1018 Q1021 I1022 Y156 R157 F180 Y191 Y192 K195 Y196 W232 L235 Q236 Q239 I240
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4nh5, PDBe:4nh5, PDBj:4nh5
PDBsum4nh5
PubMed24486018
UniProtQ9UPY3|DICER_HUMAN Endoribonuclease Dicer (Gene Name=DICER1)

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