Structure of PDB 4ngg Chain A

Receptor sequence
>4nggA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPH
FPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEYCVL
PLNVVNDSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDA
VIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDL
TNLNQPLLDVDHTSSRLNLLTPRRKAKWESLQNKQILVPELCAIHPIPAS
LWRKAVCLPSILYRLHC
3D structure
PDB4ngg A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A Y926 R927 F950 S952 Y961 Y962 Y966 W1014 Q1021 I1022 Y156 R157 F180 S182 Y191 Y192 Y196 W228 Q235 I236
BS02 PO4 A R778 R811 S984 R23 R56 S214
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4ngg, PDBe:4ngg, PDBj:4ngg
PDBsum4ngg
PubMed24486018
UniProtQ9UPY3|DICER_HUMAN Endoribonuclease Dicer (Gene Name=DICER1)

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