Structure of PDB 4ngf Chain A

Receptor sequence
>4ngfA (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPH
FPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYIFSHILRYCVLPL
NVVSTLDIDFKFMEDIEKSETKETPFVFKLEDYQDAVIIPRYRNFDQPHR
FYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTS
SRLNLLTPRPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVC
LPSILYRLHC
3D structure
PDB4ngf A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
ChainA
Resolution3.101 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A Q931 H933 S984 K1011 W1014 Q147 H149 S200 K218 W221
BS02 rna A Y926 R927 F950 S952 F958 Y961 Y962 K965 Y966 S1006 R1010 W1014 L1017 Q1021 I1022 Y142 R143 F166 S168 F174 Y177 Y178 K181 Y182 S213 R217 W221 L224 Q228 I229
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4ngf, PDBe:4ngf, PDBj:4ngf
PDBsum4ngf
PubMed24486018
UniProtQ9UPY3|DICER_HUMAN Endoribonuclease Dicer (Gene Name=DICER1)

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