Structure of PDB 4ngd Chain A

Receptor sequence
>4ngdA (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPH
FPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEKPAL
AYCVLPLNVVSSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLED
YQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKY
NLDLTNLNQPLLDVDHTSSRLNLLTPRHLPLSSAEKRKAKWESLQNKQIL
VPELCAIHPIPASLWRKAVCLPSILYRLHC
3D structure
PDB4ngd A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
ChainA
Resolution1.958 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A Y926 R927 F950 F958 Y961 Y962 K965 Y966 S1006 W1014 L1017 Q1018 Q1021 I1022 Y160 R161 F184 F192 Y195 Y196 K199 Y200 S233 W241 L244 Q245 Q248 I249
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4ngd, PDBe:4ngd, PDBj:4ngd
PDBsum4ngd
PubMed24486018
UniProtQ9UPY3|DICER_HUMAN Endoribonuclease Dicer (Gene Name=DICER1)

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