Structure of PDB 4nfn Chain A

Receptor sequence
>4nfnA (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
DILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPK
QVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQ
PRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRK
CYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDD
LWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLF
LDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKAG
3D structure
PDB4nfn The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.
ChainA
Resolution1.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2KC A I40 I48 A61 K63 E77 V105 M107 Q110 N159 D176 I19 I27 A40 K42 E56 V84 M86 Q89 N138 D155 MOAD: ic50=120nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4nfn, PDBe:4nfn, PDBj:4nfn
PDBsum4nfn
PubMed24637750
UniProtQ5TCY1|TTBK1_HUMAN Tau-tubulin kinase 1 (Gene Name=TTBK1)

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