Structure of PDB 4neh Chain A

Receptor sequence
>4nehA (length=1084) Species: 9606 (Homo sapiens) [Search protein sequence]
FNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAADQTGGLYQC
GYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRN
MYLTGLCFLLGPTQLTQRLPVSRQECPRQEQDIVFLIDGSGSISSRNFAT
MMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLASV
HQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDY
KDVIPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDF
DALKDIQNQLKEKIFAIEGTETTSSSSFELEMAQEGFSAVFTPDGPVLGA
VGSFTWSGGAFLYPPNMDPTFINMSQENVDMRDSYLGYSTELALWKGVQS
LVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDS
DGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWG
RFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHS
QRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVL
WVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSR
DLQSSVTLDLALDPGRLSPRATFQETKTRSLSRVRVLGLKAHCENFNLLL
PSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEK
NCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTI
TFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLI
FRGGAQITFLATFDVSPKAVLGDRLLLTANVSSESNTPRTSKTTFQLELP
VKYAVYTVVSSHEQFTKYLCFSESEEKESHVAMHRYQVNNLGQRDLPVSI
NFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPV
LDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSV
AEITFDTSVYSQLPGQEAFMRAQTTTVLEKYKPG
3D structure
PDB4neh An internal ligand-bound, metastable state of a leukocyte integrin, alpha X beta 2.
ChainA
Resolution2.7505 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D574 T576 D578 L580 D582 D574 T576 D578 L580 D582
BS02 MG A S140 S142 T207 S140 S142 T207
BS03 CA A D511 N513 D515 L517 D519 D511 N513 D515 L517 D519
BS04 CA A D447 D449 D451 S453 D455 D447 D449 D451 S453 D455
Gene Ontology
Molecular Function
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding
GO:0038023 signaling receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0009887 animal organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0030335 positive regulation of cell migration
GO:0031643 positive regulation of myelination
GO:0033627 cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0045766 positive regulation of angiogenesis
GO:0051607 defense response to virus
GO:0098609 cell-cell adhesion
GO:1905956 positive regulation of endothelial tube morphogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0030667 secretory granule membrane
GO:0034689 integrin alphaX-beta2 complex
GO:0070821 tertiary granule membrane
GO:0101003 ficolin-1-rich granule membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4neh, PDBe:4neh, PDBj:4neh
PDBsum4neh
PubMed24385486
UniProtP20702|ITAX_HUMAN Integrin alpha-X (Gene Name=ITGAX)

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