Structure of PDB 4ne2 Chain A

Receptor sequence
>4ne2A (length=304) Species: 507522 (Klebsiella pneumoniae 342) [Search protein sequence]
LMTPYLQFNRHQWAALRTLTEDEITRLKGINEDLSLEEVAEIYLPLSRLL
NFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALL
SRWPEHRHVELITTDGFLHPNSVLKERGLMKKKGFPQSYDMHRLVKFVSD
LKSGVPQATAPVYSHLIYDVIPDGDKTVAQPDILILEGLNVLQSGMDYPH
DPHHVFVSDFVDFSIYVDAPEELLKSWYINRFLKFREGAFTDPDSYFHNY
AKLSKEEAVDIATSLWNEINLMNLKENILPTRERASLIMTKSANHSVNQV
RLRK
3D structure
PDB4ne2 Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A N43 D45 A98 G100 K101 S102 T103 R243 H307 N31 D33 A86 G88 K89 S90 T91 R231 H295
BS02 SH2 A D127 H177 Y180 Y240 R243 F244 F259 N282 D115 H165 Y168 Y228 R231 F232 F247 N270
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:4ne2, PDBe:4ne2, PDBj:4ne2
PDBsum4ne2
PubMed24470271
UniProtB5XYG3|COAA_KLEP3 Pantothenate kinase (Gene Name=coaA)

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