Structure of PDB 4ncn Chain A

Receptor sequence
>4ncnA (length=344) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
NKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFP
VEAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGSSLCNIAI
LVVDIMHGLEPQTIESLRLLRERKTPFVVALNKIDRLYGWKKIENNGFRE
SFALQNKAVQNEFRNRLDQVKLQFAEQGFNSELFYENKNFARYVSLVPTS
AHTGEGIPDMLKLIVQLCQERMASSLMYLSELQATVLEVKAIEGFGVTID
VILSNGILREGDRIVLCGLEGPIKTNIRALLTPAPMRELRIKGQYIHHKE
VKAAQGVKISAPGLEGAIAGSRLLVVGPDDDEEELEEEVESDLQ
3D structure
PDB4ncn eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
ChainA
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A V532 D533 T534 G535 K536 T537 K538 Q549 I556 T557 G597 N648 K649 D651 R652 S716 A717 H718 V16 D17 T18 G19 K20 T21 K22 Q33 I40 T41 G81 N132 K133 D135 R136 S200 A201 H202 PDBbind-CN: -logKd/Ki=5.67,Kd=2.12uM
BS02 MG A T537 T557 T21 T41
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4ncn, PDBe:4ncn, PDBj:4ncn
PDBsum4ncn
PubMed24686316
UniProtG0S8G9|IF2P_CHATD Eukaryotic translation initiation factor 5B (Gene Name=CTHT_0029840)

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