Structure of PDB 4ncj Chain A

Receptor sequence
>4ncjA (length=311) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence]
MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLLDAILVGLYWP
LRIKDIKKDEFTKVGARDTYIDLIFEKDGTKYRITRRFLKGYSSGEIHAM
KRLVGNEWKHVTEPSSKAISAFMEKLIPYNIFLNAIYIRQGQIDAILESD
EAREKVVREVLNLKYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRA
EENKVRLFVVWEGKERPLTFLSGGERIALGLAFELAMSLYLAGEISLLIL
DEPTPYLDEERRRKLITIMERYLKKIPQVILVSHDEELKDAADHVIRISL
ENGSSKVEVVS
3D structure
PDB4ncj ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R12 S13 G33 S34 G35 K36 S37 S38 K63 V64 R12 S13 G33 S34 G35 K36 S37 S38 K63 V64
BS02 BEF A N32 K36 Q140 N32 K36 Q140
BS03 MG A S37 Q140 S37 Q140
BS04 ADP A K763 Y764 F791 S793 E796 K192 Y193 F220 S222 E225
BS05 BEF A S793 G795 S222 G224
Gene Ontology
Molecular Function
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006302 double-strand break repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4ncj, PDBe:4ncj, PDBj:4ncj
PDBsum4ncj
PubMed24493214
UniProtP58301|RAD50_PYRFU DNA double-strand break repair Rad50 ATPase (Gene Name=rad50)

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