Structure of PDB 4ncf Chain A

Receptor sequence
>4ncfA (length=448) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
DLRSPICCILGHVDTGKTKLLDKIRQTNVQAGGITQQIGATYFPIDAIKA
KTKVMAEYEKQTFDVPGLLVIDTPGHESFSNLRSRGSSLCNIAILVIDIM
HGLEQQTIESIKLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSFAKQS
RAVQEEFQSRYSKIQLELAEQGLNSELYFQNKNMSKYVSIVPTSAVTGEG
VPDLLWLLLELTQKRMSKQLMYLSHVEATILEVKVVEGFGTTIDVILSNG
YLREGDRIVLCGMNGPIVTNIRALLTPQPLRELRLKSEYVHHKEVKAALG
VKIAANDLEKAVSGSRLLVVGPEDDEDELMDDVMDDLTGLLDSVDTTGKG
VVVQASTLGSLEALLDFLKDMKIPVMSIGLGPVYKRDVMKASTMLEKAPE
YAVMLCFDVKVDKEAEQYAEQEGIKIFNADVIYHLFDSFTAYQEKLLE
3D structure
PDB4ncf eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
ChainA
Resolution3.015 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A D415 G417 K418 T419 K420 N530 K531 D533 R534 S598 A599 V600 D14 G16 K17 T18 K19 N126 K127 D129 R130 S194 A195 V196
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4ncf, PDBe:4ncf, PDBj:4ncf
PDBsum4ncf
PubMed24686316
UniProtP39730|IF2P_YEAST Eukaryotic translation initiation factor 5B (Gene Name=FUN12)

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