Structure of PDB 4nce Chain A

Receptor sequence
>4nceA (length=163) Species: 392809 (Influenza A virus (A/Victoria/3/1975(H3N2))) [Search protein sequence]
SSFSFGGFTFKRTSGSSIKREEEVLTGNLQTLKIRVHEGYEEFTMVGKRA
TAILRKATRRLVQLIVSGKDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNF
VNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEHIDNVMGMVGVLPDMTPS
TEMSMRGIRVSKM
3D structure
PDB4nce Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MGT A F323 R355 H357 E361 F363 K376 F404 Q406 N429 H432 F3 R35 H37 E41 F43 K56 F84 Q86 N109 H112
BS02 11H A T351 L352 K353 F420 V421 P430 T31 L32 K33 F100 V101 P110
BS03 11H A M458 G459 M138 G139
External links
PDB RCSB:4nce, PDBe:4nce, PDBj:4nce
PDBsum4nce
PubMed25019388
UniProtP31345|PB2_I75A3 Polymerase basic protein 2 (Gene Name=PB2)

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