Structure of PDB 4nb4 Chain A

Receptor sequence
>4nb4A (length=265) Species: 282458 (Staphylococcus aureus subsp. aureus MRSA252) [Search protein sequence]
MKVGIDAGGTLIKIVQEQDNQRTFKTELTKNIDQVVEWLNQQQIEKLCLT
GGNAGVIAENINIPAQIFVEFDAASQGLGILLKEQGHDLADYIFANVGTG
TSLHYFDGQSQRRVGGIGTGGGMIQGLGYLLSQITDYKQLTDMAQHGDRN
TIDLKVRHIYKDTEPPIPGDLTAANFGHVLHHLDFTPSNKLAAVIGVVGE
VVTTMAITVAREFKTENIVYIGSSFHNNALLRKVVEDYTVLRGCKPYYVE
NGAFSGAIGALYLEK
3D structure
PDB4nb4 Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus.
ChainA
Resolution2.25 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G8 G9 T10 L11 K13 G98 T99 G121 Q125 Y137 S225 S226 G8 G9 T10 L11 K13 G98 T99 G121 Q125 Y137 S223 S224
BS02 SH3 A E70 F71 T99 G100 R113 G116 I117 E70 F71 T99 G100 R113 G116 I117
BS03 SH3 A L171 T172 E202 Y240 L171 T172 E200 Y238
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4nb4, PDBe:4nb4, PDBj:4nb4
PDBsum4nb4
PubMed24470271
UniProtQ6G7I0|COAW_STAAS Type II pantothenate kinase (Gene Name=coaW)

[Back to BioLiP]