Structure of PDB 4na4 Chain A

Receptor sequence
>4na4A (length=505) Species: 10090 (Mus musculus) [Search protein sequence]
KKWLGTPIEEMRKMPRCGIHLPSLRPSASHTVTVRVDLLRAGEVPKPFPT
HYKDLWDNKHVKMPCSEQNLYPVTAGSRWELIQTALLNKFTRPQNLKDAI
LKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNI
CTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYP
DINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPE
WERCEKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQEEI
RFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHED
GSEKDDWQRRCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGV
PSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSEL
MRDIYSMHTFLTERKLDVGKVYKLLLRYYNEECRNCSTPGPDIKLYPFIY
HAVES
3D structure
PDB4na4 Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1R A T718 I719 E720 F731 N733 V746 Q747 E748 E749 Y788 N862 G864 G866 A867 F868 F895 T268 I269 E270 F281 N283 V296 Q297 E298 E299 Y338 N412 G414 G416 A417 F418 F445 PDBbind-CN: -logKd/Ki=6.92,IC50=120nM
Gene Ontology
Molecular Function
GO:0004649 poly(ADP-ribose) glycohydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006282 regulation of DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4na4, PDBe:4na4, PDBj:4na4
PDBsum4na4
PubMed24465839
UniProtO88622|PARG_MOUSE Poly(ADP-ribose) glycohydrolase (Gene Name=Parg)

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