Structure of PDB 4n8r Chain A

Receptor sequence
>4n8rA (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
DPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIAS
FSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQM
DKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQP
GRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPH
3D structure
PDB4n8r Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site.
ChainA
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K08 A A271 L436 F438 F439 I442 A9 L174 F176 F177 I180 MOAD: ic50=16.8uM
PDBbind-CN: -logKd/Ki=5.00,IC50~10uM
BindingDB: Kd=2050nM,IC50=10000nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4n8r, PDBe:4n8r, PDBj:4n8r
PDBsum4n8r
PubMed24704507
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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