Structure of PDB 4n83 Chain A

Receptor sequence
>4n83A (length=285) Species: 388919 (Streptococcus sanguinis SK36) [Search protein sequence]
TYYKAINWNAIEDVIDKSTWEKLTEQFWLDTRIPLSNDLDDWRKLSHKEK
DLVGKVFGGLTLLDTLQSESGVDALRKDVRTAHEEAVFNNIQFMESVHAK
SYSSIFSTLNTKSEIDEIFAWTNTNPYLQKKAEIINEIYLNGTALEKKIA
SVFLETFLFYSGFFTPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGYKF
QLAFNELPEDEQEKLKEWMYDLLYTLYENEEGYTESLYDTVGWTEEVKTF
LRYNANKALMNLGQDPLFPDSADDVNPIVMNGIST
3D structure
PDB4n83 Streptococcus sanguinis Class Ib Ribonucleotide Reductase: HIGH ACTIVITY WITH BOTH IRON AND MANGANESE COFACTORS AND STRUCTURAL INSIGHTS.
ChainA
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y104 D190
Catalytic site (residue number reindexed from 1) Y102 D188
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A E97 E157 E191 H194 E95 E155 E189 H192
BS02 MN A D66 E97 H100 E157 E191 D64 E95 H98 E155 E189
Gene Ontology
Molecular Function
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process
Cellular Component
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4n83, PDBe:4n83, PDBj:4n83
PDBsum4n83
PubMed24381172
UniProtA3CLZ4

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