Structure of PDB 4n7e Chain A

Receptor sequence
>4n7eA (length=653) Species: 9606 (Homo sapiens) [Search protein sequence]
GRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPQSK
LYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSR
GGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSK
NFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLG
KSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLP
SVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRH
LYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKP
ENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGS
VGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRP
INVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESTS
QWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRL
RKSSMCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELK
GHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFL
SPE
3D structure
PDB4n7e The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2JQ A Y271 F273 G274 F281 A282 S283 R292 I294 F317 Y318 Y362 Y211 F213 G214 F221 A222 S223 R232 I234 F257 Y258 Y302 PDBbind-CN: -logKd/Ki=6.48,IC50=330nM
BindingDB: Ki=429nM,IC50=450nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4n7e, PDBe:4n7e, PDBj:4n7e
PDBsum4n7e
PubMed24355129
UniProtQ99523|SORT_HUMAN Sortilin (Gene Name=SORT1)

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