Structure of PDB 4n7b Chain A

Receptor sequence

>4n7bA (length=318) Species: 5833 (Plasmodium falciparum)

PNKILYLINPRGFCKGVSRAIETVEECLKLFKPPIYVKHKIVHNDIVCKK
LEKEGAIFIEDLNDVPDGHILIYSAHGISPQIREIAKKKKLIEIDATCPL
VNKVHVYVQMKAKENYDIILIGYKNHVEVIGTYNEAPHCTHIVENVNDVD
KLNFPLNKKLFYVTQTTLSMDDCALIVQKLKNKFPHIETIPSGSICYATT
NRQTALNKICTKCDLTIVVGSSSSSNAKKLVYSSQIRNVPAVLLNTVHDL
DQQILKNVNKIALTSAASTPEQETQKFVNLLTNPPFNYTLQNFDGAHENV
PKWKLPKNFLHMIKEREK

3D structure

• PDB: 4n7b Structure of the (E)-4-hydroxy-3-methyl-but-2-enyl-diphosphate reductase from Plasmodium falciparum.
• Chain: A
• Resolution: 2.198 Å

Enzymatic activity

• Enzyme Commision number: 1.17.7.4: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	F3S	A	C14 G16 C98 T166 C196	C14 G16 C98 T166 C196

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0051539 4 iron, 4 sulfur cluster binding
• GO:0051745 4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity

Biological Process

• GO:0008299 isoprenoid biosynthetic process
• GO:0010322 regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
• GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
• GO:0050992 dimethylallyl diphosphate biosynthetic process

Cellular Component

• GO:0020011 apicoplast

External links

• PDB: RCSB:4n7b, PDBe:4n7b, PDBj:4n7b
• PDBsum: 4n7b
• PubMed: 24188825
• UniProt: Q8I295|ISPH_PLAF7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, apicoplast (Gene Name=LytB)