Structure of PDB 4n78 Chain A

Receptor sequence
>4n78A (length=1184) Species: 9606 (Homo sapiens) [Search protein sequence]
VTLEDALSNVDLLEELPLGIARYIEQATVHSSMNEMLEEGQEYAVMLYTW
RSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERF
CGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHS
AYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEE
LLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDA
KKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTS
SGSSPQYNICEQMIQIREDHMRFISELARYSAQKTDAEYRKLFDLALQGL
QLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEK
FALVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQ
AIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPFDIKVPRRA
VGPSSTQLYMVRTMLESLIAKTLRSSLEGPTILDIEKFHRESFFYTHLIN
FSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKE
ASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLA
DQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQL
LGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRM
THKLLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCY
NGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRN
FVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMP
KICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFC
LLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPL
HLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDP
IWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGL
HWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVER
IRKFQILNDEIITILDKYLKEHVRCFQPPIHQSL
3D structure
PDB4n78 The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton.
ChainA
Resolution2.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L1080 E1084 R1085 L1086 L1023 E1027 R1028 L1029
Gene Ontology
Molecular Function
GO:0000340 RNA 7-methylguanosine cap binding
GO:0003779 actin binding
GO:0005515 protein binding
GO:0030371 translation repressor activity
GO:0031267 small GTPase binding
GO:0051015 actin filament binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006417 regulation of translation
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0008360 regulation of cell shape
GO:0010592 positive regulation of lamellipodium assembly
GO:0016601 Rac protein signal transduction
GO:0017148 negative regulation of translation
GO:0030032 lamellipodium assembly
GO:0030154 cell differentiation
GO:0030833 regulation of actin filament polymerization
GO:0031175 neuron projection development
GO:0031529 ruffle organization
GO:0031641 regulation of myelination
GO:0032869 cellular response to insulin stimulus
GO:0045773 positive regulation of axon extension
GO:0048675 axon extension
GO:0050772 positive regulation of axonogenesis
GO:0050890 cognition
GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway
GO:0051602 response to electrical stimulus
GO:0097484 dendrite extension
GO:0099563 modification of synaptic structure
GO:0099578 regulation of translation at postsynapse, modulating synaptic transmission
GO:1900006 positive regulation of dendrite development
GO:1900029 positive regulation of ruffle assembly
GO:1903422 negative regulation of synaptic vesicle recycling
GO:1905274 regulation of modification of postsynaptic actin cytoskeleton
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
GO:0001726 ruffle
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0030027 lamellipodium
GO:0031209 SCAR complex
GO:0031252 cell leading edge
GO:0032433 filopodium tip
GO:0034774 secretory granule lumen
GO:0035580 specific granule lumen
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0044294 dendritic growth cone
GO:0044295 axonal growth cone
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0060076 excitatory synapse
GO:0070062 extracellular exosome
GO:0090724 central region of growth cone
GO:0090725 peripheral region of growth cone
GO:0098794 postsynapse
GO:1904724 tertiary granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4n78, PDBe:4n78, PDBj:4n78
PDBsum4n78
PubMed24439376
UniProtQ7L576|CYFP1_HUMAN Cytoplasmic FMR1-interacting protein 1 (Gene Name=CYFIP1)

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