Structure of PDB 4n5t Chain A

Receptor sequence
>4n5tA (length=90) Species: 7955 (Danio rerio) [Search protein sequence]
LPGEGTQVHPRAPLLQILKVAGAQEEVFTVKEVMHYLGQYIMMKQLYDKQ
RQHIVHCHDDPLGELLEVGSFSVKNPSPLYEMLKRNLVIL
3D structure
PDB4n5t Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A M50 G54 I57 M58 Y63 Q68 H69 V89 L95 Y96 M34 G38 I41 M42 Y47 Q52 H53 V73 L79 Y80
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4n5t, PDBe:4n5t, PDBj:4n5t
PDBsum4n5t
PubMed23946421
UniProtQ7ZUW7|MDM4_DANRE Protein Mdm4 (Gene Name=mdm4)

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