Structure of PDB 4n5m Chain A

Receptor sequence
>4n5mA (length=246) Species: 381666 (Cupriavidus necator H16) [Search protein sequence]
MTQRIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKA
LGFDFIASEGNVADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKM
TRADWDAVIDTNLTSLFNVTKQVIDGMADRGWGRIVNISSVNGQKGQFGQ
TNYSTAKAGLHGFTMALAQEVATKGVTVNTVSPGYIATDMVKAIRQDVLD
KIVATIPVKRLGLPEEIASICAWLSSEESGFSTGADFSLNGGLHMG
3D structure
PDB4n5m Crystal structure of (R)-3-hydroxybutyryl-CoA dehydrogenase PhaB from Ralstonia eutropha
ChainA
Resolution1.34 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N112 S140 Y153 K157
Catalytic site (residue number reindexed from 1) N112 S140 Y153 K157
Enzyme Commision number 1.1.1.36: acetoacetyl-CoA reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CAA A D94 Q147 F148 Q150 G184 Y185 M190 V191 I194 R195 D94 Q147 F148 Q150 G184 Y185 M190 V191 I194 R195
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0018454 acetoacetyl-CoA reductase activity
Biological Process
GO:0042619 poly-hydroxybutyrate biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4n5m, PDBe:4n5m, PDBj:4n5m
PDBsum4n5m
PubMed24211201
UniProtP14697|PHAB_CUPNH Acetoacetyl-CoA reductase (Gene Name=phaB)

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