Structure of PDB 4n4y Chain A

Receptor sequence

>4n4yA (length=551) Species: 274 (Thermus thermophilus) [Search protein sequence]

SRVYEAYPEKKATLYFLVLGFLALIVGSLFGPFQALNYGNVDAYPLLKRL
LPFVQSYYQGLTLHGVLNAIVFTQLFAQAIMVYLPARELNMRPNMGLMWL
SWWMAFIGLVVAALPLLANEATVLYTFYPPLKGHWAFYLGASVFVLSTWV
SIYIVLDLWRRWKAANPGKVTPLVTYMAVVFWLMWFLASLGLVLEAVLFL
LPWSFGLVEGVDPLVARTLFWWTVHPIVYFWLLPAYAIIYTILPKQAGGK
LVSDPMARLAFLLFLLLSTPVGFHHQFADPGIDPTWKMIHSVLTLFVAVP
SLMTAFTVAASLEFAGRLRGGRGLFGWIRALPWDNPAFVAPVLGLLGFIP
GGAGGIVNASFTLDYVVHNTAWVPGHFHLQVASLVTLTAMGSLYWLLPNL
TGKPISDAQRRLGLAVVWLWFLGMMIMAVGLHWAGLLNVPRRAYIAQVPD
AYPHAAVPMVFNVLAGIVLLVALLLFIYGLFSVLLSRERKPELAEAPLPF
AEVIEDRRLVLAMDRIGFWFAVAAILVVLAYGPTLVQLFGHLNPVPGWRL
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3D structure

PDB

4n4y Structure of Recombinant Cytochrome ba3 Oxidase mutant G232V from Thermus thermophilus

Chain

Resolution

2.9 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H72 P101 Y133 S155 T156 H233 I235 Y237 Y248 H282 H283 S309 G331 H384 F385 H386 R449 R450
Catalytic site (residue number reindexed from 1)	H64 P93 Y125 S147 T148 H225 I227 Y229 Y240 H274 H275 S301 G323 H376 F377 H378 R441 R442
Enzyme Commision number	7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CU	A	H233 H282 H283	H225 H274 H275
BS02	HEM	A	G39 Q42 A43 Y46 Y65 L69 H72 N76 Y133 F385 H386 A390 T394 M432 M435 R449 R450	G31 Q34 A35 Y38 Y57 L61 H64 N68 Y125 F377 H378 A382 T386 M424 M427 R441 R442
BS03	HAS	A	Y133 W229 V236 Y237 W239 H282 H283 S309 A313 A317 L353 F356 G360 G363 N366 A367 D372 H376 H384 F385 Q388 V389 R449	Y125 W221 V228 Y229 W231 H274 H275 S301 A305 A309 L345 F348 G352 G355 N358 A359 D364 H368 H376 F377 Q380 V381 R441

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0006119	oxidative phosphorylation
GO:0009060	aerobic respiration
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4n4y, PDBe:4n4y, PDBj:4n4y
PDBsum	4n4y
PubMed
UniProt	Q5SJ79\|COX1_THET8 Cytochrome c oxidase subunit 1 (Gene Name=cbaA)

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