Structure of PDB 4n4v Chain A

Receptor sequence
>4n4vA (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
QGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKV
VNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAY
IGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCR
VTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPE
YLITYQIMKPE
3D structure
PDB4n4v Structure-based design of 2-aminopyridine oxazolidinones as potent and selective tankyrase inhibitors.
ChainA
Resolution2.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1234 H1237 C1242 C1245 C131 H134 C139 C142
BS02 2GY A H1184 S1186 P1187 F1188 A1191 F1197 D1198 H1201 F1208 Y1213 H81 S83 P84 F85 A88 F94 D95 H98 F105 Y110 MOAD: ic50=0.002uM
PDBbind-CN: -logKd/Ki=8.70,IC50=2nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4n4v, PDBe:4n4v, PDBj:4n4v
PDBsum4n4v
PubMed24900633
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

[Back to BioLiP]