Structure of PDB 4n49 Chain A

Receptor sequence
>4n49A (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]
VDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKRKMIIEDETEF
CGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKM
ANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWR
KKWHAKGFGMTLKGPNDFKLEDFYSFEPYYGEGGIDGDGDITRPENISAF
RNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLMALSIV
RTGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANSERYVV
CKGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDY
MIRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQA
RV
3D structure
PDB4n49 Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A N234 A236 C277 A278 G279 P280 G281 G282 F283 L302 G334 D335 I336 D364 L383 N94 A96 C137 A138 G139 P140 G141 G142 F143 L162 G189 D190 I191 D219 L238
BS02 MGT A K203 F206 D207 R218 E373 N374 N439 K63 F66 D67 R78 E228 N229 N294
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4n49, PDBe:4n49, PDBj:4n49
PDBsum4n49
PubMed24402442
UniProtQ8N1G2|CMTR1_HUMAN Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (Gene Name=CMTR1)

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