Structure of PDB 4n14 Chain A

Receptor sequence
>4n14A (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]
CRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSG
DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM
TSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG
LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC
PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL
ISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAAD
ETLRLWRCFELDP
3D structure
PDB4n14 Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WR7 A L176 D177 Y207 W209 I216 L12 D13 Y43 W45 I52 MOAD: Ki=23uM
BindingDB: Kd=123000nM
Gene Ontology
Molecular Function
GO:0010997 anaphase-promoting complex binding
GO:0097027 ubiquitin-protein transferase activator activity
Biological Process
GO:1904668 positive regulation of ubiquitin protein ligase activity

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Molecular Function
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Biological Process
External links
PDB RCSB:4n14, PDBe:4n14, PDBj:4n14
PDBsum4n14
PubMed25156254
UniProtQ12834|CDC20_HUMAN Cell division cycle protein 20 homolog (Gene Name=CDC20)

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