Structure of PDB 4n0o Chain A

Receptor sequence
>4n0oA (length=395) Species: 299386 (Equine arteritis virus Bucyrus) [Search protein sequence]
MSAVCTVCGAAPVAKSACGGWFCGNCVPYHAGHCHTTSLFACGHDIMYRS
TYCTMCEGSQMVPKVPHPILDHLLCHIDYGSKEETLVVADRTTSPPGRYK
VGHKVVAVDVGGNIVFGCGPGSHIAVPLQDTLKGVVVNKALKNAAASEYV
EGPPGSGKTFHLVKDVLAVVGSATLVVPTHASMLDCINKLKQAGADPYFV
VPKYTVLDFPRPGSGNITVRLPQVGTSEGETFVDEVAYFSPVDLARILTQ
GRVKGYGDLNQLGCVGPASVPRNLWLRHFVSLEPLRVCHRFGAAVCDLIK
GIYPYYEPAPHTTKVVFVPNPDFEKGVVITAYHKDRGLGHRTIDSIQGCT
FPVVTLRLPTPQSLTRPRAVVAVTRASQELYIYDPFDQLSGLLKF
3D structure
PDB4n0o Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.
ChainA
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.21.-
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y81 R102 H186 Q229 Y244 C270 V271 Y338 H339 T348 D350 R374 Y79 R98 H180 Q223 Y238 C264 V265 Y332 H333 T342 D344 R368
BS02 ZN A C17 H29 H32 C33 C18 H30 H33 C34
BS03 ZN A C4 C7 C25 C5 C8 C26
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:4n0o, PDBe:4n0o, PDBj:4n0o
PDBsum4n0o
PubMed24369429
UniProtP19811|RPOA_EAVBU Replicase polyprotein 1ab (Gene Name=rep)

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