Structure of PDB 4mzr Chain A

Receptor sequence
>4mzrA (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
SSSVPSQKTYQGSYGFRLGFLHSGTAKFGTCTYSPALNKMFVQLAKTVPV
QLYVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERSSDSDGLAPPQH
LIRVEGNLRAEYLDDPNTFRHSVVVPYEPPEVGSDYTTIYFKFMCNSSCM
GGMNRRPILVIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRKKT
MDGEYFTLQIRGRERFEQFRERNEALELKDAQAT
3D structure
PDB4mzr Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A S241 R273 C275 A276 R280 S148 R180 C182 A183 R187 PDBbind-CN: Kd=6.93nM
BS02 dna A R248 R283 R155 R190 PDBbind-CN: Kd=6.93nM
BS03 ZN A C176 H179 C242 C83 H86 C149
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
GO:0051262 protein tetramerization
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4mzr, PDBe:4mzr, PDBj:4mzr
PDBsum4mzr
PubMed24374182
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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