Structure of PDB 4mz7 Chain A

Receptor sequence

>4mz7A (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDIYFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4mz7 Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

Chain

Resolution

1.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	H167 H206 D207 D311	H55 H94 D95 D193
BS02	DGT	A	Q149 L150 R164 H215 D309 D311 K312 Y315 D319 R366 Y374 Q375	Q37 L38 R52 H103 D191 D193 K194 Y197 D201 R248 Y256 Q257
BS03	DGT	A	V156 F157 R372 H376 K377	V44 F45 R254 H258 K259
BS04	DGT	A	K116 I118 D137 R145	K4 I6 D25 R33
BS05	DGT	A	Y155 V156 V378 R451	Y43 V44 V260 R333
BS06	DTP	A	V117 N119	V5 N7

External links

PDB	RCSB:4mz7, PDBe:4mz7, PDBj:4mz7
PDBsum	4mz7
PubMed	24217394
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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