Structure of PDB 4mys Chain A

Receptor sequence
>4mysA (length=252) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MILHAQAKHGKPGLPWLVFLHGFSGDCHEWQEVGEAFADYSRLYVDLPGH
GGSAAISVDGFDDVTDLLRKTLVSYNILDFWLVGYSLGGRVAMMAACQGL
AGLCGVIVEGGHPGLQNAEQRAERQRSDRQWVQRFLTEPLTAVFADWYQQ
PVFASLNDDQRRELVALRSNNNGATLAAMLEATSLAVQPDLRANLSARTF
AFYYLCGERDSKFRALAAELAADCHVIPRAGHNAHRENPAGVIASLAQIL
RF
3D structure
PDB4mys Molecular basis of the general base catalysis of an alpha / beta-hydrolase catalytic triad.
ChainA
Resolution1.423 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.99.20: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 164 A G22 F23 Y85 S86 L87 R90 W147 Y148 F153 G22 F23 Y85 S86 L87 R90 W147 Y148 F153
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0070205 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
Biological Process
GO:0009234 menaquinone biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4mys, PDBe:4mys, PDBj:4mys
PDBsum4mys
PubMed24737327
UniProtP37355|MENH_ECOLI 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (Gene Name=menH)

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