Structure of PDB 4myq Chain A

Receptor sequence
>4myqA (length=345) Species: 9606 (Homo sapiens) [Search protein sequence]
SISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQ
ERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLS
TPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDES
VLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHM
SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLE
LYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIV
HPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQCQGLMEKFQF
3D structure
PDB4myq Structural basis for the design of selective phosphodiesterase 4B inhibitors.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 19T A Y405 M519 N567 I582 F586 M603 Q615 F618 L674 K677 Y82 M196 N244 I259 F263 M280 Q292 F295 L339 K342 MOAD: ic50=32nM
PDBbind-CN: -logKd/Ki=7.49,IC50=32nM
BindingDB: IC50=32nM
BS02 ZN A H410 H446 D447 D564 H87 H123 D124 D241
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4myq, PDBe:4myq, PDBj:4myq
PDBsum4myq
PubMed24361374
UniProtQ07343|PDE4B_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4B (Gene Name=PDE4B)

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