Structure of PDB 4myk Chain A

Receptor sequence
>4mykA (length=288) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
TDDPRLLSLFSAQREEDADIVIIGFPYDEGCVRNGGRAGAKKGPAAFRFF
LQRLGSVNNLELNVDASHLKLYDAGDITASTLEEAHEKLESKVFTVLARG
AFPFVIGGGNDQSAPNGRAMLRAFPGDVGVINVDSHLDVRGTPFRQLLEE
SSFSGKRFVEFACQGSQCGALHAQYVRDHQGHLMWLSEVRKKGAVAALED
AFGLTGKNTFFSFDVDSLKSSDMPGVSCPAAVGLSAQEAFDMCFLAGKTP
TVMMMDMSELNPLVEEYRSPRVAVYMFYHFVLGFATRP
3D structure
PDB4myk Formiminoglutamase from trypanosoma cruzi is an arginase-like manganese metalloenzyme.
ChainA
Resolution1.518 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N114 D138 H140 D142 D228 D230 E273
Catalytic site (residue number reindexed from 1) N110 D134 H136 D138 D214 D216 E259
Enzyme Commision number 3.5.3.8: formimidoylglutamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A N114 D138 D228 N110 D134 D214
BS02 MN A D138 H140 D228 D230 D134 H136 D214 D216
Gene Ontology
Molecular Function
GO:0008783 agmatinase activity
GO:0046872 metal ion binding
Biological Process
GO:0033389 putrescine biosynthetic process from arginine, using agmatinase

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Molecular Function
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Biological Process
External links
PDB RCSB:4myk, PDBe:4myk, PDBj:4myk
PDBsum4myk
PubMed24261485
UniProtQ4DSA0

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