Structure of PDB 4mxz Chain A

Receptor sequence
>4mxzA (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA
FLQEAQVLKKLRHEKLVQLYAVVSEEPIYIVMEYMSKGSLLDFLKGETGK
YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFG
LARLIEFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMV
NREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE
DYFTSTEPQYQPGENL
3D structure
PDB4mxz A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity.
ChainA
Resolution2.582 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D130 R132 A134 N135 D148 F157
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DB8 A A293 K295 E310 V323 I336 M338 Y340 M341 S342 L393 D404 A37 K39 E54 V67 I80 M82 Y84 M85 S86 L137 D148 BindingDB: IC50=3.8nM,Kd=1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4mxz, PDBe:4mxz, PDBj:4mxz
PDBsum4mxz
PubMed24292070
UniProtP12931|SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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