Structure of PDB 4mwu Chain A

Receptor sequence
>4mwuA (length=388) Species: 11320 (Influenza A virus) [Search protein sequence]
RNFNNLTKGLCTINSWHIYGKDNAVRIGESSDVLVTREPYVSCDPDECRF
YALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSS
TSCHDGKSRMSICISGPNNNASAVVWYNRRPVAEINTWARNILRTQESEC
VCHNGVCPVVFTDGSATGPADTRIYYFKEGKILKWESLTGTAKHIEECSC
YGERTGITCTCRDNWQGSNRPVIQIDPVAMTHTSQYICSPVLTDNPRPND
PNIGKCNDPYPGNNNNGVKGFSYLDGANTWLGRTISTASRSGYEMLKVPN
ALTDDRSKPIQGQTIVLNADWSGYSGSFMDYWAEGDCYRACFYVELIRGR
PKEDKVWWTSNSIVSMCSSTEFLGQWNWPDGAKIEYFL
3D structure
PDB4mwu Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses
ChainA
Resolution1.799 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D152 E279 R294 R372 Y406
Catalytic site (residue number reindexed from 1) D70 E197 R212 R290 Y324
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D295 G299 D326 N348 D213 G217 D244 N266
BS02 LNV A R119 E120 D152 R153 W180 E229 A248 E278 R294 R372 Y406 R37 E38 D70 R71 W98 E147 A166 E196 R212 R290 Y324 MOAD: ic50=3.24nM
PDBbind-CN: -logKd/Ki=8.49,IC50=3.24nM
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4mwu, PDBe:4mwu, PDBj:4mwu
PDBsum4mwu
PubMed24165891
UniProtA0A024E3Q2

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