Structure of PDB 4mwo Chain A

Receptor sequence
>4mwoA (length=193) Species: 9606 (Homo sapiens) [Search protein sequence]
ALRVLVDMDGVLADFEGGFLRKFRARFPDQPFIALEDRRGFWVSEQYGRL
RPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMASLQNTDVFICTSPIK
MFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDITGAE
PTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRP
3D structure
PDB4mwo Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5'(3')-nucleotidases.
ChainA
Resolution1.67 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D41 D43 D176
Catalytic site (residue number reindexed from 1) D7 D9 D142
Enzyme Commision number 3.1.3.-
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 2E2 A D43 F49 F75 W76 V77 S78 W96 S131 R163 D9 F15 F41 W42 V43 S44 W62 S97 R129 MOAD: Ki=7.9uM
Gene Ontology
Molecular Function
GO:0008253 5'-nucleotidase activity
Biological Process
GO:0009264 deoxyribonucleotide catabolic process

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:4mwo, PDBe:4mwo, PDBj:4mwo
PDBsum4mwo
PubMed25178098
UniProtQ9NPB1|NT5M_HUMAN 5'(3')-deoxyribonucleotidase, mitochondrial (Gene Name=NT5M)

[Back to BioLiP]