Structure of PDB 4mvw Chain A

Receptor sequence
>4mvwA (length=523) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
KVEKVFFVTSPIYYVNAAPHIGHVYSTLITDVIGRYHRVKGERVFALTGT
DEHGQKVAEAAKQKQVSPYDFTTAVAGEFKKCFEQMDYSIDYFIRTTNEQ
HKAVVKELWTKLEQKGDIYLGRYEGWYSISDESFLTPQNITDGVDKDGNP
CKVSLESGHVVTWVSEENYMFRLSAFRERLLEWYHANPGCIVPEFRRREV
IRAVEKGLPDLSVSRARATLHNWAIPVPGNPDHCVYVWLDALTNYLTGSR
LRVDESGKEVSLVDDFNELERFPADVHVIGKDILKFHAIYWPAFLLSAGL
PLPKKIVAHGWWTKDRKVFDPVEKAEEFGYDALKYFLLRESGFSDDGDYS
DKNMIARLNGELADTLGNLVMRCTSAKINVNGEWPSPAAYTEEDESLIQL
IKDLPGTADHYYLIPDIQKAIIAVFDVLRAINAYVTDMAPWKLVKTDPER
LRTVLYITLEGVRVTTLLLSPILPRKSVVIFDMLGVPEVHRKGIENFEFG
AVPPGTRLGPAVEGEVLFSKRST
3D structure
PDB4mvw Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
ChainA
Resolution2.901 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H256 H259 S364 D367 S390 S393
Catalytic site (residue number reindexed from 1) H20 H23 S128 D131 S154 S157
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MET A P247 I248 Y250 D287 W474 L478 K550 P11 I12 Y14 D51 W238 L242 K314
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4mvw, PDBe:4mvw, PDBj:4mvw
PDBsum4mvw
PubMed24743796
UniProtQ38C91

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