Structure of PDB 4mvf Chain A

Receptor sequence
>4mvfA (length=408) Species: 5839 (Plasmodium falciparum K1) [Search protein sequence]
LILCHSGKLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLK
NINRFFQEIEIMKKLDHPNIVKLYETYENDNYIYLIMELCSGRELFDSII
ENGSFTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLL
KIIDFGLSKNLKYDKKCDIWSSGVIMYTLLCGYPPFYCFYENDWGSISSD
AKNLITKLLTYNPNERCTIEEALNHPWITQMTKSHVELSSTLLKNLKNFK
KENELKKIALTIIAKHLCDVEINNLRNIFIALDVDNSGTLSSQEILDGLK
KIGYQKIPPDIHQVLRDIDSNASGQIHYTDFLAATIDKQTYLKKEVCLIP
FKFFDIDGNGKISVEELKRIFGPLIDKAIDSLLQEVDLNGDGEIDFHEFM
LMMSKLEH
3D structure
PDB4mvf P. falciparum Calcium-Dependent Protein Kinase 2 (PfCDPK2): First Crystal Structure and Virtual Ligand Screening
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D192 K194 E196 N197 D213
Catalytic site (residue number reindexed from 1) D133 K135 E137 N138 D154
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A L78 Q80 V86 A99 K101 L148 C149 S150 G151 L199 I212 D213 L19 Q21 V27 A40 K42 L89 C90 S91 G92 L140 I153 D154
BS02 CA A D383 D385 S387 T389 E394 D283 D285 S287 T289 E294
BS03 CA A D455 D457 N459 K461 E466 D355 D357 N359 K361 E366
BS04 CA A D493 N495 D497 E499 E504 D387 N389 D391 E393 E398
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calcium/calmodulin-dependent protein kinase activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0044024 histone H2AS1 kinase activity
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4mvf, PDBe:4mvf, PDBj:4mvf
PDBsum4mvf
PubMed
UniProtO15865|CDPK2_PLAFK Calcium-dependent protein kinase 2 (Gene Name=CDPK2)

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