Structure of PDB 4mv7 Chain A

Receptor sequence

>4mv7A (length=414) Species: 71421 (Haemophilus influenzae Rd KW20)

MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETIC
IGPAPSAKSYLNIPAIIAAAEVTGADAIHPGYGFLSENADFAEQVERSGF
TFIGPTADVIRLMGDKVSAIKAMKKAGVPCVPGSAKNKEIAKRIGYPIII
RVVRSEDALEESIAMTKAEMEKYLENPRHVEIQVLADTHGNAVYLAERDC
SMQRRHQKVVEEAPAPGITEEVRRDIGSRCANACVEIGYRGAGTFEFLYE
NGEFYFIEMNTRIQVEHPVTEMITGVDLVKEQLRIAAGLPISFKQEDIKV
KGHAMECRINAEDPKTFLPSPGKVNHLHSPGGLGVRWDSHVYGGYTVPPH
YDSMIAKLITYGDTREVAIRRMQNALSETIIDGIKTNIPLHELILEDENF
QKGGTNIHYLEKKL

3D structure

• PDB: 4mv7 Structural Analysis of Substrate, Reaction Intermediate, and Product Binding in Haemophilus influenzae Biotin Carboxylase.
• Chain: A
• Resolution: 1.73 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K116 H209 R235 T274 E276 E288 N290 R292 E296 R338
• Catalytic site (residue number reindexed from 1): K116 H179 R205 T244 E246 E258 N260 R262 E266 R308
• Enzyme Commision number: 6.3.4.14: biotin carboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PPF	A	K238 R292 Q294 V295 E296 R338	K208 R262 Q264 V265 E266 R308

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0003989 acetyl-CoA carboxylase activity
• GO:0004075 biotin carboxylase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006633 fatty acid biosynthetic process
• GO:2001295 malonyl-CoA biosynthetic process

External links

• PDB: RCSB:4mv7, PDBe:4mv7, PDBj:4mv7
• PDBsum: 4mv7
• PubMed: 26020841
• UniProt: P43873|ACCC_HAEIN Biotin carboxylase (Gene Name=accC)